Chronic mitochondrial uncoupling treatment prevents acute cold-induced oxidative stress in birds

@article{Stier2014ChronicMU,
  title={Chronic mitochondrial uncoupling treatment prevents acute cold-induced oxidative stress in birds},
  author={Antoine Stier and Sylvie Massemin and François Criscuolo},
  journal={Journal of Comparative Physiology B},
  year={2014},
  volume={184},
  pages={1021-1029}
}
Endotherms have evolved two major types of thermogenesis that allow them to actively produce heat in response to cold exposure, either through muscular activity (i.e. shivering thermogenesis) or through futile electro-chemical cycles (i.e. non-shivering thermogenesis). Amongst the latter, mitochondrial uncoupling is of key importance because it is suggested to drive heat production at a low cost in terms of oxidative stress. While this has been experimentally shown in mammals, the oxidative… CONTINUE READING
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