Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

@article{Lee2006ChronicMS,
  title={Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus},
  author={Kuem-Ju Lee and Sung-jin Kim and S H Kim and Song-hyen Choi and You-Chan Shin and Sang-Ha Park and Bo-hyun Moon and Eujin Cho and Min-Soo Lee and S Choi and Boe-Gwun Chun and Kyung-ho Shin},
  journal={Experimental & Molecular Medicine},
  year={2006},
  volume={38},
  pages={44-54}
}
New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not clear whether chronic stress affects neurogenesis. To determine whether chronic mild stress (CMS) influences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or… CONTINUE READING