Chronic microglial activation and progressive dopaminergic neurotoxicity.

@article{Block2007ChronicMA,
  title={Chronic microglial activation and progressive dopaminergic neurotoxicity.},
  author={Michelle L. Block and Ji-Un Hong},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 5},
  pages={
          1127-32
        }
}
PD (Parkinson's disease) is characterized by the selective and progressive loss of DA neurons (dopaminergic neurons) in the substantia nigra. Inflammation and activation of microglia, the resident innate immune cell in the brain, have been strongly linked to neurodegenerative diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently… CONTINUE READING

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