Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury.

@article{Wagner2009ChronicMT,
  title={Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury.},
  author={Amy K Wagner and Laura L Drewencki and Xiangbai Chen and Flaubert R S Santos and Amina S. Khan and Rashed Harun and Gonzalo E. Torres and Adrian C Michael and C. Edward Dixon},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 4},
  pages={
          986-97
        }
}
Traumatic brain injury (TBI) results in functional deficits that often are effectively treated clinically with the neurostimulant, methylphenidate (MPH). We hypothesized that daily MPH administration would reverse striatal neurotransmission deficits observed in the controlled cortical impact (CCI) model of TBI. CCI or naïve rats received daily injections of MPH (5 mg/kg) or saline for 14 days and were assessed on day 15 using fast scan cyclic voltammetry. Dopamine (DA) transporter (DAT… CONTINUE READING

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