• DOI:10.1038/s41380-019-0617-8
Corpus ID: 209169489

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

@article{Greening2019ChronicMI,
  title={Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome},
  author={D. Greening and M. Notaras and Maoshan Chen and R. Xu and J. D. Smith and L. Cheng and R. Simpson and A. Hill and M. van den Buuse},
  journal={Molecular Psychiatry},
  year={2019},
  pages={1 - 17}
}

D. Greening, M. Notaras, +6 authors M. van den Buuse

Published 2019

Biology, Medicine

Molecular Psychiatry

Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived neurotrophic factor (BDNF) is implicated in both Meth effects and schizophrenia. We therefore studied the long-term effects of chronic Meth exposure in transgenic mice engineered to harbor the human BDNFVal66Met polymorphism expressed via endogenous mouse promoters. These mice were chronically treated with an escalating… CONTINUE READING

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