Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

@article{Greening2019ChronicMI,
  title={Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome},
  author={David W. Greening and Michael J. Notaras and Maoshan Chen and Rong Xu and Joel D. Smith and Lesley Cheng and Richard J. Simpson and Andrew F. Hill and Maarten van den Buuse},
  journal={Molecular Psychiatry},
  year={2019},
  volume={26},
  pages={4431-4447}
}
Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived neurotrophic factor (BDNF) is implicated in both Meth effects and schizophrenia. We therefore studied the long-term effects of chronic Meth exposure in transgenic mice engineered to harbor the human BDNF Val66Met polymorphism expressed via endogenous mouse promoters. These mice were chronically treated with an escalating… 
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