Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Abstract

Background/Objectives:The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.Methods:We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.Results:Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.Conclusions:This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

DOI: 10.1038/ijo.2017.136

Cite this paper

@article{Dudele2017ChronicMI, title={Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner}, author={Anete Dudele and Karin S\orig Hougaard and Mads Kj\olby and Marianne Elisabet Hokland and Gr\onfeldt Winther and Betina Elfving and Gregers Wegener and Amie L Nielsen and A Larsen and Martha Kampp N\ohr and Steen B\onl\okke Pedersen and Tianyun Wang and S\orens Lund}, journal={International Journal of Obesity}, year={2017}, volume={41}, pages={1420-1426} }