Chronic manganism: A long-term follow-up study with a new dopamine terminal biomarker of 18F-FP-(+)-DTBZ (18F-AV-133) brain PET scan.

@article{Huang2015ChronicMA,
  title={Chronic manganism: A long-term follow-up study with a new dopamine terminal biomarker of 18F-FP-(+)-DTBZ (18F-AV-133) brain PET scan.},
  author={Chu-Yun Huang and Chi-Hung Liu and Eusden Tsao and Chia-Ju Hsieh and Y H Weng and Ing-Tsung Hsiao and T. G. Yen and Kun-Ju Lin and C-C Huang},
  journal={Journal of the neurological sciences},
  year={2015},
  volume={353 1-2},
  pages={102-6}
}
Recent experimental studies revealed that dopamine neuron dysfunction in chronic manganism may be due to a reduced capacity of dopamine release in the striatum. The findings imposed further difficulty in the differential diagnosis between manganism and IPD. We conducted a long-term clinical follow-up study of 4 manganism patients, applying a new tracer (18)F-9-fluoropropyl-(+)-dihydrotetrabenazine ((18)F-AV-133) with positron emission tomography (PET). Twenty age-matched subjects including 4… CONTINUE READING