Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats.

@article{Deblon2012ChronicMI,
  title={Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats.},
  author={Nicolas Deblon and Lee Bourgoin and Christelle Veyrat-Durebex and Mathieu Peyrou and Manlio Vinciguerra and Aur{\'e}lie Caillon and Christine Maeder and Margot Fournier and Xavier Montet and Françoise Rohner-Jeanrenaud and Maria Gabriella Foti},
  journal={British journal of pharmacology},
  year={2012},
  volume={165 7},
  pages={2325-40}
}
BACKGROUND AND PURPOSE mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigated the mechanisms associated with the diabetogenic effects of chronic Sirolimus administration in rats and in in vitro cell cultures. EXPERIMENTAL APPROACH Sirolimus was administered to rats fed… CONTINUE READING