Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.

@article{Ramsay2013ChronicLL,
  title={Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.},
  author={Alan G Ramsay and Rachel Evans and Shahryar Kiaii and Lena Svensson and Nancy Hogg and John G Gribben},
  journal={Blood},
  year={2013},
  volume={121 14},
  pages={2704-14}
}
T lymphocytes have an essential role in adaptive immunity and rely on the activation of integrin lymphocyte function-associated antigen-1 (LFA-1) to mediate cell arrest and migration. In cancer, malignant cells modify the immune microenvironment to block effective host antitumor responses. We show for the first time that CD4 and CD8 T cells from patients with chronic lymphocytic leukemia (CLL) exhibit globally impaired LFA-1-mediated migration and that this defect is mediated by direct tumor… CONTINUE READING
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Lenalidomide consolidation appears to prolong time to retreatment after first-line chemoimmunotherapy for patients with previously untreated CLL

  • TD Shanafelt, H Tun, CA Hanson
  • Blood (ASH Annual ASH Meeting Abstracts)
  • 2011
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