Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.

@article{Grgn2005ChronicLL,
  title={Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.},
  author={G{\"u}ll{\"u} G{\"o}rg{\"u}n and Tobias A. W. Holderried and David Zahrieh and Donna S Neuberg and John G Gribben},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 7},
  pages={
          1797-805
        }
}
To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic leukemia (CLL) with those from age-matched healthy donors. Although the cells analyzed were not part of the malignant clone, analysis revealed differentially expressed genes, mainly involved in cell differentiation in CD4 cells and defects in cytoskeleton formation, vesicle trafficking, and cytotoxicity… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 123 CITATIONS, ESTIMATED 61% COVERAGE

Identification of p38 beta as a therapeutic target for the treatment of Sézary Syndrome

  • The Journal of investigative dermatology
  • 2015
VIEW 4 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

Investigating the role of T-cells in chronic lymphocytic leukemia

VIEW 10 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

1 Role of LFA-1 and ICAM-1 in cancer 2

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Tumor infiltrating lymphocytes need LFA-1 to adhere to target cells

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 15 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019

References

Publications referenced by this paper.