Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins.

@article{Widhopf2004ChronicLL,
  title={Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins.},
  author={George F. Widhopf and Laura Z. Rassenti and Traci L Toy and John G Gribben and William G Wierda and Thomas J. Kipps},
  journal={Blood},
  year={2004},
  volume={104 8},
  pages={2499-504}
}
We examined the immunoglobulin (Ig) heavy chain variable region genes (V(H) genes) used by leukemia cells of 1220 unrelated patients with chronic lymphocytic leukemia (CLL). We found 1188 (97%) expressed Ig encoded by a single Ig V(H) subgroup, the most common of which was V(H)3 (571 or 48.1%), followed by V(H)1 (319 or 26.8%) and V(H)4 (241 or 20.2%). Using allele-specific primers, we found 13.8% of all samples (n = 164) used one major V(H)1-69 allele, designated 51p1, 163 of which were not… CONTINUE READING
108 Extracted Citations
46 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 108 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 46 references

Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation VIRTUALLY IDENTICAL IG EXPRESSED IN CLL

  • K Lin, PD Sherrington, M Dennis, Z Matrai, JC Cawley, AR. Pettitt
  • BLOOD,
  • 2004

Similar Papers

Loading similar papers…