Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.

@article{Contri2005ChronicLL,
  title={Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.},
  author={Antonella Contri and Anna Maria Brunati and Livio Trentin and Anna Cabrelle and Marta Miorin and Luca Cesaro and Lorenzo A Pinna and Renato Zambello and Gianpietro Semenzato and Arianna Donella-Deana},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 2},
  pages={369-78}
}
B cell chronic lymphocytic leukemia (B-CLL) is a neoplastic disorder characterized by accumulation of B lymphocytes due to uncontrolled growth and resistance to apoptosis. Analysis of B cells freshly isolated from 40 patients with chronic lymphocytic leukemia demonstrated that the Src kinase Lyn, the switch molecule that couples the B cell receptor to downstream signaling, displays anomalous properties. Lyn is remarkably overexpressed at the protein level in leukemic cells as compared with… CONTINUE READING
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Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

  • K Saijo
  • Nat. Immunol
  • 2003
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