Chronic lymphocytic leukemia (CLL) is a malignant disorder of mature B cells characterised by monoclonal expansion in blood, bone marrow, and lymphoid organs of cells arrested in the G0/G1 stage of the cell cycle

Abstract

Signals through the B-cell antigen receptor (BCR) are important for the survival of chronic lymphocytic leukaemia (CLL) cells. Therefore, factors that influence these signals have important pathophysiological roles in this disease. One key mediator of BCR signalling is protein kinase C β (PKCβ), which regulates activation of I-κB kinases and deactivation of… (More)

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