Chronic lymphocytic leukemia: a clinical and molecular heterogenous disease.

  title={Chronic lymphocytic leukemia: a clinical and molecular heterogenous disease.},
  author={Ana Eugenia Rodr{\'i}guez-Vicente and Marcos Gonz{\'a}lez D{\'i}az and Jes{\'u}s-Mar{\'i}a Hern{\'a}ndez-Rivas},
  journal={Cancer genetics},
  volume={206 3},
The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL), with survival times ranging from months to decades, reflects its biological diversity. Our understanding of the biology of CLL has helped us identify several markers of prognostic significance, by which CLL can be differentiated into several distinct diseases. The presence of specific chromosomal abnormalities is a prognostic indicator of disease progression and survival. Conventional cytogenetic analyses have… CONTINUE READING


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