Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment.

@article{Hallek2017ChronicLL,
  title={Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment.},
  author={Michael J Hallek},
  journal={American journal of hematology},
  year={2017},
  volume={92 9},
  pages={946-965}
}
DISEASE OVERVIEW Chronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. The disease typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B cells. DIAGNOSIS The diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B lymphocytes, which identify a clonal B-cell population carrying the CD5 antigen and B… CONTINUE READING
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