Chronic lymphocytic leukaemia

  title={Chronic lymphocytic leukaemia},
  author={Thomas J. Kipps and Freda K Stevenson and Catherine J. Wu and Carlo M. Croce and Graham Packham and William G Wierda and S. Edward O'Brien and John G Gribben and Kanti R Rai},
  journal={Nature Reviews Disease Primers},
Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and lymphoid tissues. Signalling via surface immunoglobulin, which constitutes the major part of the B cell receptor, and several genetic alterations play a part in CLL pathogenesis, in addition to interactions between CLL cells and other cell types, such as stromal cells, T cells and nurse-like cells in the lymph nodes. The… CONTINUE READING
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