Chronic lung allograft dysfunction: evolving practice

@article{Vos2015ChronicLA,
  title={Chronic lung allograft dysfunction: evolving practice},
  author={Robin Vos and Stijn E. Verleden and Geert M. Verleden},
  journal={Current Opinion in Organ Transplantation},
  year={2015},
  volume={20},
  pages={483–491}
}
Purpose of reviewChronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight the latest insights and current controversies regarding the new CLAD terminology, underlying… 
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34 Citations

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Ex vivo lung perfusion is a promising technology with the potential for increasing the lung donor pool, evolving extracorporeal support strategies coupled with effective rehabilitation will effectively bridge critically ill patients to transplant, and research efforts intended to increase the understanding of the underlying mechanisms of chronic lung allograft dysfunction will ultimately lead to the development of effective therapies.
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TLDR
The current state of the literature on chronic lung allograft dysfunction is reviewed and light is shed on classification systems, corresponding clinical and morphological changes, key cellular players and underlying molecular pathways, as well as on emerging diagnostic and therapeutic approaches.
Precision medicine: integration of genetics and functional genomics in prediction of bronchiolitis obliterans after lung transplantation
TLDR
Genetic polymorphisms and gene expression changes are associated with the development of BOS and future genome wide studies are needed to identify easily accessible biomarkers for prediction of B OS toward precision medicine.
Lung Transplant Pathology: An Overview on Current Entities and Procedures.
Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction.
  • A. Moniodis, K. Townsend, +11 authors H. Goldberg
  • Medicine
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2018
Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction
TLDR
OCT examination of small AD shows potential as a diagnostic indicator for CLAD and CLAD phenotype and merits further exploration.
Recent advances in lung transplantation
TLDR
The goal of this manuscript is to review salient recent and evolving advances in the field of lung transplantation to increase post-transplant survival.
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