Chronic low-level Pb exposure during development decreases the expression of the voltage-dependent anion channel in auditory neurons of the brainstem.

@article{Prins2010ChronicLP,
  title={Chronic low-level Pb exposure during development decreases the expression of the voltage-dependent anion channel in auditory neurons of the brainstem.},
  author={John Marcus Prins and Diane M. Brooks and Charles M. Thompson and Diana I Lurie},
  journal={Neurotoxicology},
  year={2010},
  volume={31 6},
  pages={
          662-73
        }
}
  • John Marcus Prins, Diane M. Brooks, +1 author Diana I Lurie
  • Published 2010
  • Biology, Medicine
  • Neurotoxicology
  • Lead (Pb) exposure is a risk factor for neurological dysfunction. How Pb produces these behavioral deficits is unknown, but Pb exposure during development is associated with auditory temporal processing deficits in both humans and animals. Pb disrupts cellular energy metabolism and efficient energy production is crucial for auditory neurons to maintain high rates of synaptic activity. The voltage-dependent anion channel (VDAC) is involved in the regulation of mitochondrial physiology and is a… CONTINUE READING

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