• DOI:10.1016/0002-9149(85)90302-9
Corpus ID: 40024750

Chronic lorcainide therapy for symptomatic premature ventricular complexes: efficacy, pharmacokinetics and evidence for norlorcainide antiarrhythmic effect.

@article{Mead1985ChronicLT,
  title={Chronic lorcainide therapy for symptomatic premature ventricular complexes: efficacy, pharmacokinetics and evidence for norlorcainide antiarrhythmic effect.},
  author={R. Mead and D. Keefe and R. Kates and R. Winkle},
  journal={The American journal of cardiology},
  year={1985},
  volume={55 1},
  pages={
          72-8
        }
}

R. Mead, D. Keefe, +1 author R. Winkle

Published 1985

Medicine

The American journal of cardiology

Chronic premature ventricular complexes (PVCs) have been effectively suppressed by oral lorcainide as reported in previous short-term studies. The plasma level-effect relation of lorcainide may be affected by the possible cardioactivity of norlorcainide, a metabolite that accumulates after repeated oral doses. This study evaluated the long-term efficacy of lorcainide in suppressing chronic symptomatic PVCs, and examined the relation of arrhythmia suppression to plasma concentrations of… CONTINUE READING

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