Chronic liver injury, TGF-beta, and cancer.

  title={Chronic liver injury, TGF-beta, and cancer.},
  author={Daniel M. Bissell},
  journal={Experimental & molecular medicine},
  volume={33 4},
Cells termed myofibroblasts are prominent in the injury response of all epithelial tissues. They exhibit proliferation, migration, production of collagen and other extracellular matrix (ECM) molecules, and contraction, all for containing the injury and closing the wound. When the injury is limited in time, the final stage of the repair involves a dismantling of the cellular apparatus and restoration of normal tissue structure. With multiple cycles of repair, however, there is net accumulation… CONTINUE READING


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