Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.

@article{Vogel2004ChronicLD,
  title={Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.},
  author={Arndt Vogel and Inge E T van den Berg and Muhsen J Al-Dhalimy and John D. Groopman and Ching-nan Ou and Olga P Ryabinina and Mihail S Iordanov and Milton L Finegold and Markus Grompe},
  journal={Hepatology},
  year={2004},
  volume={39 2},
  pages={433-43}
}
The murine model of hereditary tyrosinemia type 1 (HT1) was used to analyze the relationship between chronic liver disease and programmed cell death in vivo. In healthy fumarylacetoacetate hydrolase deficient mice (Fah(-/-)), protected from liver injury by the drug 2-(2- nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), the tyrosine metabolite homogentisic acid (HGA) caused rapid hepatocyte death. In contrast, all mice survived the same otherwise lethal dose of HGA if they had… CONTINUE READING

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