Chronic lithium treatment affects rat brain and serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) levels.

@article{Maayan2004ChronicLT,
  title={Chronic lithium treatment affects rat brain and serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) levels.},
  author={Rachel Maayan and Galit Shaltiel and Michael Poyurovsky and Edward Ramadan and Oren Morad and Allon Nechmad and Abraham Weizman and Galila Agam},
  journal={The international journal of neuropsychopharmacology},
  year={2004},
  volume={7 1},
  pages={71-5}
}
Lithium (Li) is an established effective treatment for bipolar disorder. However, the molecular mechanism of its action is still unknown. Dehydroepiandrosterone (DHEA) and its sulphate ester (DHEA-S) are adrenal hormones also synthesized de novo in the brain as neurosteroids. Recent studies have suggested that DHEA has mood-elevating properties and may demonstrate antidepressant effects. 3(2)-Phosphoadenosine 5-phosphate (PAP) phosphatase is a novel Li-inhibitable enzyme involved in sulphation… CONTINUE READING