Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain.

@article{ODonnell2000ChronicLA,
  title={Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain.},
  author={Tina O'Donnell and Susan Rotzinger and Thomas T Nakashima and Chris C Hanstock and Michele L Ulrich and Peter H. Silverstone},
  journal={Brain research},
  year={2000},
  volume={880 1-2},
  pages={84-91}
}
One of the mechanisms underlying lithium's efficacy as a mood stabilizer in bipolar disorder has been proposed to be via its effects on the phosphoinositol cycle (PI-cycle), where it is an inhibitor of the enzyme converting inositol monophosphates to myo-inositol. In contrast, sodium valproate, another commonly used mood stabilizer, appears to have no direct effects on this enzyme and was thus believed to have a different mechanism of action. In the present study, high resolution nuclear… CONTINUE READING
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