Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions.

@article{Murer1998ChronicLI,
  title={Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions.},
  author={Mario Gustavo Murer and Gustavo Dziewczapolski and Liliana B. Menalled and Mar{\'i}a del Carmen Garc{\'i}a and Yves Agid and Oscar S. Gershanik and Rita Raisman-Vozari},
  journal={Annals of neurology},
  year={1998},
  volume={43 5},
  pages={561-75}
}
Orally administered levodopa remains the most effective symptomatic treatment for Parkinson's disease (PD). The introduction of levodopa therapy is often delayed, however, because of the fear that it might be toxic for the remaining dopaminergic neurons and, thus, accelerate the deterioration of patients. However, in vivo evidence of levodopa toxicity is scarce. We have evaluated the effects of a 6-month oral levodopa treatment on several dopaminergic markers, in rats with moderate or severe 6… CONTINUE READING
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