Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport.

@article{Yaspelkis1999ChronicLA,
  title={Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport.},
  author={Ben B. Yaspelkis and L Ansari and E L Ramey and George J. Holland and Steven F. Loy},
  journal={Metabolism: clinical and experimental},
  year={1999},
  volume={48 5},
  pages={671-6}
}
Leptin, the product of the ob gene, has been shown to reduce fat mass, food intake, hyperglycemia, and hyperinsulinemia and to increase whole-body glucose disposal. However, it is unknown if leptin improves insulin action in skeletal muscle. Therefore, the purpose of this investigation was to determine if chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport. Sixty-nine female Sprague-Dawley rats (240 to 250 g) were randomly assigned to one of… CONTINUE READING