Chronic lentiviral expression of inwardly rectifying K+ channels (Kir2.1) reduces neuronal activity and downregulates voltage-gated potassium currents in hippocampus.

@article{Okada2008ChronicLE,
  title={Chronic lentiviral expression of inwardly rectifying K+ channels (Kir2.1) reduces neuronal activity and downregulates voltage-gated potassium currents in hippocampus.},
  author={Masayoshi Okada and Hiroko Matsuda},
  journal={Neuroscience},
  year={2008},
  volume={156 2},
  pages={289-97}
}
Strongly inwardly rectifying K+ (Kir2) channels are endogenously expressed in rat brains and have recently been used as a tool to reduce the neuronal activity. But little is known about the role of Kir2 channels and the chronic effect of the reduced activity on the intrinsic excitability of neurons. Here we constructed a lentiviral vector that coexpressed Kir2.1 and GFP (LvKir2.1) and infected the vector to the hippocampal slice cultures. The LvKir2.1-infected CA1 neurons showed clear inwardly… CONTINUE READING

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