Chronic lead exposure attenuates sensitization to the locomotor-stimulating effects of cocaine.

@article{Nation1996ChronicLE,
  title={Chronic lead exposure attenuates sensitization to the locomotor-stimulating effects of cocaine.},
  author={Jack R. Nation and C. T. Alviso R. W. Pekela J. Gross Lawrence Livermore and R T Burkey},
  journal={Drug and alcohol dependence},
  year={1996},
  volume={41 2},
  pages={143-9}
}
Adult male rats were exposed to a water supply containing 500 ppm lead acetate (Lead Group), or a comparable concentration of sodium acetate (Control Group), for 30 days prior to commencing testing for behavioral sensitization to cocaine. Locomotor activity (total distance (cm) travelled) was monitored for animals in both exposure conditions across 14 daily 1 h test sessions. Across successive sessions, baseline activity was recorded for a 20-min baseline period, at which time half the animals… CONTINUE READING