Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1.

@article{Leelahavanichkul2011ChronicKD,
  title={Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1.},
  author={Asada Leelahavanichkul and Yuning George Huang and Xuzhen Hu and Hua Zhou and Takayuki Tsuji and Richard Chen and Jeffrey B. Kopp and J{\"u}rgen B. Schnermann and Peter S T Yuen and Robert A Star},
  journal={Kidney international},
  year={2011},
  volume={80 11},
  pages={1198-211}
}
We have shown that folate-induced kidney dysfunction and interstitial fibrosis predisposes mice to sepsis mortality. Agents that increase survival in normal septic mice were ineffective in a two-stage kidney disease model. Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease (CKD) to study how CKD affects acute kidney injury (AKI) induced by sepsis. We induced sepsis using cecal ligation and puncture and found that the presence of CKD intensified the severity of… CONTINUE READING

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Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
Chronic kidney disease worsens sepsis and sepsis - induced acute kidney injury by releasing High Mobility Group Box Protein-1 .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Chronic kidney disease worsens sepsis and sepsis - induced acute kidney injury by releasing High Mobility Group Box Protein-1 .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
Here we used the 5/6 nephrectomy mouse model of progressive chronic kidney disease ( CKD ) to study how CKD affects acute kidney injury ( AKI ) induced by sepsis .
We induced sepsis using cecal ligation and puncture and found that the presence of CKD intensified the severity of kidney and liver injury , cytokine release , and splenic apoptosis .
We induced sepsis using cecal ligation and puncture and found that the presence of CKD intensified the severity of kidney and liver injury , cytokine release , and splenic apoptosis .
Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
Accumulation of High Mobility Group Box Protein-1 ( HMGB1 ; a late proinflammatory cytokine released from apoptotic cells ) , vascular endothelial growth factor ( VEGF ) , tumor necrosis factor ( TNF)-α , interleukin ( IL)-6 , or IL-10 was increased in CKD or sepsis alone and to a greater extent in CKD - sepsis .
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