Chronic kidney disease of unknown aetiology and ground-water ionicity: study based on Sri Lanka

@article{Dharmawardana2014ChronicKD,
  title={Chronic kidney disease of unknown aetiology and ground-water ionicity: study based on Sri Lanka},
  author={M. Dharma-wardana and S. L. Amarasiri and N. Dharmawardene and C. R. Panabokke},
  journal={Environmental Geochemistry and Health},
  year={2014},
  volume={37},
  pages={221-231}
}
AbstractHigh incidence of chronic kidney disease of unknown aetiology (CKDU) in Sri Lanka is shown to correlate with the presence of irrigation works and rivers that bring-in ‘nonpoint source’ fertilizer runoff from intensely agricultural regions. We review previous attempts to link CKDU with As, Cd and other standard toxins. Those studies (e.g. the WHO-sponsored study), while providing a wealth of data, are inconclusive in regard to aetiology. Here, we present new proposals based on increased… Expand
Drinking Water Quality on Chronic Kidney Disease of Unknown Aetiology (CKDu) in Ulagalla Cascade, Sri Lanka
Chronic Kidney Disease of unknown aetiology (CKDu) is one of the major health issues in Northern part of Sri Lanka that recorded highest mortality and morbidity rates. The main responsible reason forExpand
Using water quality and isotope studies to inform research in chronic kidney disease of unknown aetiology endemic areas in Sri Lanka.
TLDR
The study identifies elevated concentrations of silica which requires further investigation in groundwater and provides research directions in the form of isotopic tracers and the frequency of sampling that is needed to capture potential pollutants in future groundwater quality studies in CKDu endemic areas in Sri Lanka. Expand
Groundwater fluoride as a geochemical marker in the etiology of chronic kidney disease of unknown origin in Sri Lanka
TLDR
A case study from such regions in Sri Lanka shows that Mg-rich groundwater in the hard water terrains points to a lesser CKDu prevalence, indicative of a protective role for Mg against heart ailments caused by CKDu and more detailed investigations on the mechanisms of geo-biochemical interactions of F, Na, Ca and Mg in the etiology of CKD are clearly warranted. Expand
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TLDR
This review focuses on such well-known hypotheses suspecting the relations with fluoride, hardness, major ions, heavy metals, metalloids, organic matter, agrochemical residues, pathogens, and bacterial toxins in the groundwaters of the CKDu-endemic region. Expand
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Evidence to date suggests that the disease is related to one or more environmental agents, however pinpointing a definite cause for CKDu is challenging and it is plausible that CK Du is multifactorial. Expand
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Research findings suggest that in addition to drinking water from stagnant sources that contain high ionic components, more than 10 years of exposure to environmental nephrotoxins and micronutrient malnutrition are needed to contract this fatal disease. Expand
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Progression of potential etiologies of the chronic kidney disease of unknown etiology in Sri Lanka.
TLDR
Progression of the etiologies revealed persistent interest in heavy metals of multiple origins: waterborne, foodborne, or soilborne, and secondary factors appear to act synergistically, aggravating the role of heavy metals on the onset, and the progression of CKDu. Expand
CHRONIC KIDNEY DISEASE OF MULTIFUNCTIONAL ORIGIN (CKDMFO) PREVAILING IN SRI LANKA REEVALUATED
Chronic Kidney Disease of Uncertain Aetiology seems to be caused by several factors and hence it could be best described as Chronic Kidney Disease of Multifunctional origin (CKDmfo). CKDmfo isExpand
Drinking Water Quality in Chronic Kidney Disease of Unknown Aetiology ( CKDu ) Prevalent and Non-prevalent Areas in Giradurukotte , Sri Lanka
Chronic Kidney Disease of unknown aetiology (CKDu) is increasing at an alarming rate in dry zone of Sri Lanka, and Giradurukotte is one of the endemic regions with CKDu located in Uva province. BasedExpand
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