Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis

@inproceedings{Prommer2018ChronicKD,
  title={Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis},
  author={Hans-Ulrich Prommer and Johannes Maurer and Karoline von Websky and Christian Freise and Kerstin Sommer and Hamoud Nasser and Rudi Samapati and Bettina Reglin and Pedro Guimar{\~a}es and Axel Radlach Pries and Uwe Querfeld},
  booktitle={Scientific Reports},
  year={2018}
}
Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the… CONTINUE READING
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