Chronic kidney disease aggravates arteriovenous fistula damage in rats.

@article{Langer2010ChronicKD,
  title={Chronic kidney disease aggravates arteriovenous fistula damage in rats.},
  author={Stephan Langer and Maria Kokozidou and Christian Heiss and Jennifer Kranz and Tina Kessler and Niklas Paulus and Thilo Kr{\"u}ger and Michael J. H. M. Jacobs and Christina Lente and Thomas Andreas Koeppel},
  journal={Kidney international},
  year={2010},
  volume={78 12},
  pages={1312-21}
}
Neointimal hyperplasia (NIH) and impaired dilatation are important contributors to arteriovenous fistula (AVF) failure. It is unclear whether chronic kidney disease (CKD) itself causes adverse remodeling in arterialized veins. Here we determined if CKD specifically triggers adverse effects on vascular remodeling and assessed whether these changes affect the function of AVFs. For this purpose, we used rats on a normal diet or on an adenine-rich diet to induce CKD and created a fistula between… CONTINUE READING

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