Chronic kidney disease: Mesoamerican nephropathy—new clues to the cause

@article{Johnson2013ChronicKD,
  title={Chronic kidney disease: Mesoamerican nephropathy—new clues to the cause},
  author={Richard J. Johnson and L. S{\'a}nchez-Lozada},
  journal={Nature Reviews Nephrology},
  year={2013},
  volume={9},
  pages={560-561}
}
An epidemic of chronic kidney disease of unknown aetiology has emerged in Central America and resulted in the highest rates of end-stage renal disease worldwide. New findings from the first renal biopsy study of patients with Mesoamerican nephropathy should help medical detectives to 'crack' the cause of this disease. 
Mesoamerican Nephropathy or Chronic Kidney Disease of Unknown Origin
During the last two decades, an unexplained and highly lethal epidemic of chronic kidney disease of unknown etiology has appeared or made itself evident in the Pacific Coastal lowlands of theExpand
Mesoamerican nephropathy: a novel case of kidney failure in a US ED.
TLDR
The first case of Mesoamerican nephropathy (MeN) in the emergency department is reported, suggesting that MeN is a serious and relatively novel cause of CKD. Expand
Comment: Mesoamerican nephropathy – new evidence and the need to act now
We welcome the publication ‘‘Changes in kidney function among Nicaraguan sugarcane workers,’’ 1 which raises important issues regarding the Mesoamerican nephropathy (MeN), an epidemic of chronicExpand
Update on endemic nephropathies
TLDR
Endemic nephropathies may comprise an important cause of CKD and epidemiological studies are needed to describe the occurrence and distribution of the diseases. Expand
Renal Morphology, Clinical Findings, and Progression Rate in Mesoamerican Nephropathy.
TLDR
This study confirms the renal morphology of MeN: chronicglomerular and tubulointerstitial damage with glomerulosclerosis and chronic glomerular ischemia and follow-up data show that eGFRs, on average, deteriorated. Expand
Characterization of Mesoamerican Nephropathy in a Kidney Failure Hotspot in Nicaragua.
TLDR
The results suggest that rather than being solely a consequence of CKD, hyperuricemia may play a role in MeN pathogenesis, a hypothesis that deserves further study. Expand
Dehydration-associated chronic kidney disease: a novel case of kidney failure in China
TLDR
A case of dehydration-associated CKD in a Chinese patient which shared similar etiology to Mesoamerican nephropathy is reported, and even in non-agricultural areas, this etiology of CKD should be noted to obtain a relevant history and prompt diagnosis. Expand
Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology
  • Daba Abdissa
  • Medicine
  • International journal of nephrology and renovascular disease
  • 2020
TLDR
In this review, available evidence on the risk factors, epidemiology, clinical features, treatment, and prevention of CKDu is summarized. Expand
Additional perspectives on chronic kidney disease of unknown aetiology (CKDu) in Sri Lanka – lessons learned from the WHO CKDu population prevalence study
TLDR
The objective of this paper is to discuss the recently published findings of this investigation and present additional considerations and recommendations that may enhance subsequent investigations designed to identify and understand CKDu risk factors in Sri Lanka or other countries. Expand
Mesoamerican nephropathy: geographical distribution and time trends of chronic kidney disease mortality between 1970 and 2012 in Costa Rica
TLDR
Excess CKD mortality occurs primarily in Guanacaste lowlands and was already present 4 decades ago, and stable moderate increases among women, and among men in counties without sugarcane, suggest coexisting environmental risk factors. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 18 REFERENCES
Clinical and pathological characterization of Mesoamerican nephropathy: a new kidney disease in Central America.
TLDR
The findings indicate that Mesoamerican nephropathy constitutes a previously unrecognized kidney disease with damage to both glomerular and tubulointerstitial compartments. Expand
Screening for chronic kidney disease in patients with diabetes: are we missing the point?
TLDR
The authors of this Viewpoint highlight the inadequacies of current screening practices, and argue that detection of increased urinary albumin excretion in a patient with diabetes should be a call to action. Expand
The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report.
TLDR
KDIGO has convened a workgroup to develop a global clinical practice guideline for the definition, classification, and prognosis of chronic kidney disease. Expand
Prevalence of and risk factors for chronic kidney disease in rural Nicaragua.
  • Julie O'Donnell, Matthew L Tobey, +5 authors D. Brooks
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2011
TLDR
Kidney disease appears common in residents of Quezalguaque, Nicaragua, particularly in younger men, with features most consistent with tubulointerstitial disease. Expand
Decreased kidney function of unknown cause in Nicaragua: a community-based survey.
TLDR
In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational. Expand
Mesoamerican Nephropathy : Report from the First International Research Workshop on MeN
Union Europea Programa Salud, Trabajo y Ambiente en America Central (SALTRA) Instituto Regional de Estudios en Sustancias Toxicas (IRET)
Suboptimal blood pressure control in chronic kidney disease stage 3: baseline data from a cohort study in primary care
TLDR
Suboptimal BP control was common in CKD patients with hypertension in this study, particularly those at highest risk of adverse outcomes due to diabetes and or albuminuria, and there is scope for improving BP control in people with CKD by using more antihypertensive agents in combination while considering issues of adherence and potential side effects. Expand
Prediction of kidney-related outcomes in patients with type 2 diabetes.
  • M. Jardine, J. Hata, +11 authors J. Chalmers
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 2012
TLDR
Risk scores have been developed for early and late events in diabetic nephropathy and, in the case of new-onset albuminuria, were derived from 7- and 8-variable models, respectively. Expand
Derivation and Validation of a Renal Risk Score for People With Type 2 Diabetes
TLDR
These 5-year renal risk models performed very well in two large primary care populations with type 2 diabetes, and more accurate risk stratification could facilitate earlier intervention than using eGFR and/or albuminuria alone. Expand
General medical care among patients with chronic kidney disease: opportunities for improving outcomes.
TLDR
Evidence is provided that patients with CKD may not be receiving general health and CKD care according to current recommendations and that a greater proportion of patients with diabetes tended to have claims for tests in both cohorts. Expand
...
1
2
...