Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys

  title={Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys},
  author={Lin Sun and Qi Li and Qing Li and Yuzhe Zhang and De-xiang Liu and Hong Jiang and Fang Pan and David T. Yew},
  journal={Addiction Biology},
  • Lin SunQi Li D. Yew
  • Published 1 March 2014
  • Biology, Psychology
  • Addiction Biology
Ketamine, a non‐competitive N‐methyl‐D‐aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when a single dose is given to healthy volunteers. However, understanding of the possible chronic effects of ketamine on behavior, cognitive anomalies and neurochemical homeostasis is… 

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