Chronic isoproterenol administration causes altered beta adrenoceptor-Gs-coupling in guinea pig lung.

@article{Nerme1990ChronicIA,
  title={Chronic isoproterenol administration causes altered beta adrenoceptor-Gs-coupling in guinea pig lung.},
  author={Viveca K Nerme and Tommy I Abrahamsson and Georges Vauquelin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={252 3},
  pages={1341-6}
}
Chronic administration of isoproterenol caused major changes in the molecular and functional characteristics of lung beta adrenoceptors. The dose of isoproterenol delivered by the minipumps over 7 days corresponded to approximately 60 micrograms.kg-1h-1. The agonist treatment produced an 80% decrease in the number of beta adrenoceptors in lung membranes. However, a significant proportion of the remaining receptors could still form complexes with the nucleotide regulatory protein (Gs) in the… CONTINUE READING