Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats.

@article{Bertoli2018ChronicIO,
  title={Chronic iron overload induces vascular dysfunction in resistance pulmonary arteries associated with right ventricular remodeling in rats.},
  author={Sabrina Rodrigues Bertoli and Vin{\'i}cius Bermond Marques and Emilly Martinelli Rossi and Mechthild Krause and Maria Tereza Weitzel Dias Carneiro and Maylla Ronacher Sim{\~o}es and Leonardo Dos Santos},
  journal={Toxicology letters},
  year={2018},
  volume={295},
  pages={
          296-306
        }
}
Although iron excess is toxic to the vasculature and even that pulmonary hypertension has been reported in this scenario, the role of iron overload per se remains to be clarified. This study aimed to test the effects of chronic iron-overload in rats on the morphophysiology of resistance pulmonary arteries (RPA) and right ventricle (RV) remodeling. Rats were injected with saline or iron-dextran (10, 100 and 200 mg/kg/day i.p.) for 28 days. Our results indicated increased circulating iron with… CONTINUE READING
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