Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression.

@article{Cornfield2000ChronicIP,
  title={Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression.},
  author={David N. Cornfield and Ernesto R Resnik and J. M. Herron and Steven H Abman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={279 5},
  pages={
          L857-62
        }
}
Calcium-sensitive potassium (K(Ca)) channels play a critical role in mediating perinatal pulmonary vasodilation. Because infants with persistent pulmonary hypertension of the newborn (PPHN) have blunted vasodilator responses to birth-related stimuli, we hypothesized that lung K(Ca) channel gene expression is decreased in PPHN. To test this hypothesis, we measured K(Ca) channel gene expression in distal lung homogenates from both fetal lambs with severe pulmonary hypertension caused by prolonged… CONTINUE READING

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