Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension

Abstract

Dysfunction of the NO/sGC/cGMP signaling pathway has been implicated in the pathogenesis of pulmonary hypertension (PH). Therefore, agents stimulating cGMP synthesis via sGC are important therapeutic options for treatment of PH patients. An unwanted effect of this novel class of drugs is their systemic hypotensive effect. We tested the hypothesis that… (More)
DOI: 10.18632/oncotarget.16769

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Cite this paper

@inproceedings{Amirjanians2017ChronicIA, title={Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension}, author={Matthieu Amirjanians and Bakytbek Egemnazarov and Akylbek Sydykov and Baktybek Kojonazarov and Ralf P. Brandes and Himal Luitel and Kabita Pradhan and J P Stasch and Gorden Redlich and Norbert Weissmann and Friedrich Grimminger and Werner Seeger and Hossein - Ardeschir Ghofrani and Ralph T Schermuly}, booktitle={Oncotarget}, year={2017} }