Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord.

@article{Maher2001ChronicIM,
  title={Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord.},
  author={Catherine E Maher and James C Eisenach and H L Pan and Royu Xiao and Steven R. Childers},
  journal={Brain research},
  year={2001},
  volume={895 1-2},
  pages={1-8}
}
Previous studies have shown that chronic i.v. treatment with morphine or heroin decreased mu opioid receptor activation of G-proteins in specific brain regions. The present study examined the effect of intrathecal (i.t.) morphine administration on receptor/G-protein coupling in the spinal cord. In spinal cord membranes, [35S]GTP gamma S binding was stimulated by agonists of several G-protein-coupled receptors, including mu opioid (DAMGO), delta opioid (DPDPE), GABA(B) (baclofen), cannabinoid CB… CONTINUE READING

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