Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat.

@article{Wojcik1996ChronicII,
  title={Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat.},
  author={Wadyslaw Wojcik and Peggy Swoveland and Xieping Zhang and Padmavathy Vanguri},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={278 1},
  pages={404-10}
}
The role of CRG-2 protein (murine IP-10) in experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, was tested by blocking crg-2 mRNA synthesis using chronic infusion of antisense oligonucleotides into lumbar subarachnoid space by osmotic minipumps. After injection with myelin basic protein, rats developed hind limb paralysis… CONTINUE READING