Chronic intragastric alcohol exposure causes hypoxia and oxidative stress in the rat pancreas.

Abstract

The effect of chronic enteral ethanol on pancreatic hypoxia was investigated using the hypoxia marker, pimonidazole. Male Wistar rats were fed an ethanol-containing diet for 3 weeks using an enteral model shown to cause pancreatic damage; pimonidazole (120 mg/kg i.v.) was injected 1h before sacrifice. Pimonidazole and 4-hydroxynonenal (an index of lipid… (More)

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Cite this paper

@article{McKim2003ChronicIA, title={Chronic intragastric alcohol exposure causes hypoxia and oxidative stress in the rat pancreas.}, author={Stephen E McKim and Takehiko Uesugi and James A. Raleigh and Craig McClain and Gavin E. Arteel}, journal={Archives of biochemistry and biophysics}, year={2003}, volume={417 1}, pages={34-43} }