Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries.

@article{Phillips2004ChronicIH,
  title={Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries.},
  author={Shane A Phillips and Edward Olson and Barbara J Morgan and Julian H. Lombard},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 1},
  pages={H388-93}
}
The goal of the present study was to evaluate the effects of relatively short-term chronic intermittent hypoxia (CIH) on endothelial function of resistance vessels in the skeletal muscle and cerebral circulations. Sprague-Dawley rats were exposed to 14 days of CIH (10% fraction of inspired oxygen for 1 min at 4-min intervals, 12 h/day, n = 6). Control rats (n = 6) were housed under normoxic conditions. After 14 days, resistance arteries of the gracilis muscle (GA) and middle cerebral arteries… CONTINUE READING

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