Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons.

@article{Nelson2004ChronicIE,
  title={Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons.},
  author={Thomas E. Nelson and Jeffrey G Netzeband and Donna L. Gruol},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 9},
  pages={2387-400}
}
Chronic central nervous system expression of the cytokine interleukin-6 (IL-6) is thought to contribute to the histopathological, pathophysiological, and cognitive deficits associated with various neurological disorders. However, the effects of chronic IL-6 expression on neuronal function are largely unknown. Previous studies have shown that chronic IL-6 exposure alters intrinsic electrophysiological properties and intracellular Ca2+ signalling evoked by ionotropic glutamate receptor activation… CONTINUE READING

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