Chronic insulin treatment amplifies PDGF-induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B.

@article{Zhuang2008ChronicIT,
  title={Chronic insulin treatment amplifies PDGF-induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B.},
  author={Daming Zhuang and Qinghua Pu and Bogdan Ceacareanu and Yingzi Chang and Madhulika Dixit and Aviv Hassid},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 1},
  pages={H163-73}
}
Hyperinsulinemia plays a major role in the pathogenesis of vascular disease. Restenosis occurs at an accelerated rate in hyperinsulinemia and is dependent on increased vascular smooth muscle cell movement from media to neointima. PDGF plays a critical role in mediating neointima formation in models of vascular injury. We have reported that PDGF increases the levels of protein tyrosine phosphatase PTP1B and that PTP1B suppresses PDGF-induced motility in cultured cells and that it attenuates… CONTINUE READING