Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis.

@article{Chen2004ChronicIA,
  title={Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis.},
  author={Hua Chen and Shuanfang Li and Jie Liu and Bhalchandra A. Diwan and Jeffrey C. Barrett and Michael P. Waalkes},
  journal={Carcinogenesis},
  year={2004},
  volume={25 9},
  pages={
          1779-86
        }
}
Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Global DNA hypomethylation occurs during arsenic-induced malignant transformation in rodent liver cells. DNA hypomethylation can increase gene expression, particularly when occurring in the promoter region CpG sites, and may be a non-genotoxic mechanism of carcinogenesis. Thus, in the present study liver samples of male mice exposed to 0 (control) or 45 p.p.m. arsenic (as NaAsO… CONTINUE READING

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