Chronic inhibition of nuclear factor-kappaB attenuates renal injury in the 5/6 renal ablation model.

@article{Fujihara2007ChronicIO,
  title={Chronic inhibition of nuclear factor-kappaB attenuates renal injury in the 5/6 renal ablation model.},
  author={Clarice Kazue Fujihara and Gl{\'a}ucia Rutigliano Antunes and Ana L{\'u}cia Mattar and D M Malheiros and Jos{\'e} Mauro Vieira and Roberto Zatz},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 1},
  pages={
          F92-9
        }
}
Recent studies indicated that the nuclear transcription factor, NF-kappaB, activates a number of proinflammatory genes in subjects with progressive nephropathies. We investigated whether NF-kappaB inhibition limits progressive renal injury in the 5/6 renal ablation model (Nx). Adult male Munich-Wistar rats were subdivided in four groups: S (n = 16), subjected to sham operation; S+PDTC (n = 18), sham-operated rats receiving the NF-kappaB inhibitor pyrrolidine-dithiocarbamate (PDTC; 60 mg x kg(-1… CONTINUE READING

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