Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice.

@article{Amin2012ChronicIO,
  title={Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice.},
  author={Ali H. Amin and Soo-kyoung Choi and Mar{\'i}a Luisa Gal{\'a}n and Modar Kassan and Megan I Partyka and Philip J. Kadowitz and Daniel Henrion and Mohamed Trebak and Souad Belmadani and Khalid Matrougui},
  journal={The Journal of pathology},
  year={2012},
  volume={227 2},
  pages={165-74}
}
Endoplasmic reticulum (ER) stress and inflammation are important mechanisms that underlie many of the serious consequences of type II diabetes. However, the role of ER stress and inflammation in impaired ischaemia-induced neovascularization in type II diabetes is unknown. We studied ischaemia-induced neovascularization in the hind-limb of 4-week-old db - /db- mice and their controls treated with or without the ER stress inhibitor (tauroursodeoxycholic acid, TUDCA, 150 mg/kg per day) and… CONTINUE READING
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