Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II.

@article{Richards1993ChronicIO,
  title={Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II.},
  author={Arthur Mark Richards and Gary A Wittert and Ian George Crozier and E A Espiner and Timothy G. Yandle and Hamid Ikram and Chris Frampton},
  journal={Journal of hypertension},
  year={1993},
  volume={11 4},
  pages={407-16}
}
AIM To determine the renal, endocrine and haemodynamic effects of an orally active inhibitor of the neutral endopeptidase EC 3.4.24.11 in essential hypertension. METHODS Two groups of 12 white male patients with essential hypertension were treated with candoxatril at 25 mg every 12 h (group 1) or at 200 mg every 12 h (group 2) for 5 days in double-blind, placebo-controlled, crossover studies. RESULTS Candoxatril enhanced natriuresis over the initial 48 h of treatment. Twenty-four-hour… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Similar Papers

Loading similar papers…