Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

@article{Takimoto2005ChronicIO,
  title={Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy},
  author={Eiki Takimoto and Hunter C. Champion and Man-xiang Li and Diego Belardi and Shuxun Ren and E. Ren{\'e} Rodr{\'i}guez and Djahida Bedja and Kathleen L. Gabrielson and Yibin Wang and David A. Kass},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={214-222}
}
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure. Genetically engineered hyperstimulation of guanosine 3′,5′-cyclic monophosphate (cGMP) synthesis counters this response. Here, we show that blocking the intrinsic catabolism of cGMP with an oral phosphodiesterase-5A (PDE5A) inhibitor (sildenafil) suppresses chamber and myocyte hypertrophy, and improves in vivo heart function in mice exposed to chronic pressure overload… CONTINUE READING
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