Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.

@article{Sudre2002ChronicIO,
  title={Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.},
  author={B{\'e}atrice Sudre and Pierre Broqua and Richard B. White and Doreen M Ashworth and David M. Evans and Robert Haigh and J Junien and Michel Lucien Aubert},
  journal={Diabetes},
  year={2002},
  volume={51 5},
  pages={1461-9}
}
Acute suppression of dipeptidyl peptidase IV (DPP-IV) activity improves glucose tolerance in the Zucker fatty rat, a rodent model of impaired glucose tolerance, through stabilization of glucagon-like peptide (GLP)-1. This study describes the effects of a new and potent DPP-IV inhibitor, FE 999011, which is able to suppress plasma DPP-IV activity for 12 h after a single oral administration. In the Zucker fatty rat, FE 999011 dose-dependently attenuated glucose excursion during an oral glucose… CONTINUE READING